Development of a Large-Scale Stereoselective Process for (1 R, 4 S)-4-(3, 4-Dichlorophenyl)-1, 2, 3, 4-tetrahydronaphthalen-1-amine Hydrochloride

Z Han, SG Koenig, H Zhao, X Su…

文献索引：Organic Process Research and Development, , vol. 11, # 4 p. 726 - 730

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被引用次数: 26

摘要

... Organic Process Research & Development. ... its stereoselective reduction with 9-BBN to produce the (1R)-amine center of 1. The process has been ... When successful, these processes have been applied to the plant-scale manufacture of advanced pharmaceutical intermediates. ...