Bioconjugation of biotinylated PAMAM dendrons to avidin

…, V Ladmiral, G Mantovani, DM Haddleton

文献索引：Tao, Lei; Geng, Jin; Chen, Gaojian; Xu, Yingjian; Ladmiral, Vincent; Mantovani, Giuseppe; Haddleton, David. M. Chemical Communications, 2007 , # 33 p. 3441 - 3443

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被引用次数: 16

摘要

Application of proteins and peptides as human therapeutics is developing rapidly with the discovery of novel peptides and proteins . 1,2 Many peptide derived molecules can be destroyed in the digestive system and in the circulatory system, removed by proteolytic digestion and rapid renal excretion. 3 Covalent attachment of synthetic macromolecules is an effective way to improve protein stability with reduced immunogenicity and extended plasma half-lives. 4–11 ...