Design and synthesis of small chemical inhibitors containing different scaffolds for lck SH2 domain

SH Park, SH Kang, SH Lim, HS Oh, KH Lee

文献索引：Park, See-Hyoung; Kang, Sun-Hee; Lim, Sang-Hyeong; Oh, Hyun-Sik; Lee, Keun-Hyeung Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3455 - 3459

全文：HTML全文

被引用次数: 16

摘要

On the basis of the structure of (R)-rosmarinic acid, a series of small chemical compounds with a different scaffold was synthesized as inhibitors for lck SH2 domain. From ELISA results, most of all chemical compounds showed a similar or a little lower binding activity for lck SH2 domain compared to the lead compound,(R)-rosmarinic acid. It was characterized that the backbone rigidity between two catechol substructures was required for the full ...