Tetrahedron letters

Formal total synthesis of shikonin via Dötz benzannulation

SR Pulley, B Czakó

文献索引：Pulley, Shon R.; Czako, Barbara Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5511 - 5514

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被引用次数: 24

摘要

The Dötz benzannulation reaction provides mild conditions for the construction of highly functionalized aromatic compounds. We have utilized this method for the formal total synthesis of shikonin. The key step in our approach is the application of the Dötz benzannulation reaction between Fischer a chromium carbene complex and an optically active alkyne for the construction of the aromatic skeleton. This is followed by protecting ...