N-alkoxycarbonyl amino acid N-carboxyanhydrides and N, N-dialkoxycarbonyl amino acid fluorides from N, N-diprotected amino acids

J Savrda, M Wakselman

文献索引：Savrda, J.; Wakselman, M. Journal of the Chemical Society, Chemical Communications, 1992 , # 11 p. 812 - 813

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被引用次数: 10

摘要

Activation of N,N-bis-Boc or N-Boc NZ amino acids with SOC12-DMF leads to N-protected N-carboxy amino acid anhydrides, whereas treatment with cyanuric fluoride at low temperature gives mainly N,N-bis-protected amino acid fluorides, which are efficient acylating agents. ... The renewed interest in the preparation of N-protected amino acid halides 1 and amino acid N-carboxyanhydrides (NCA)2 has recently led to the synthesis of interesting new coupling