Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives

…, CJ Huang, ZY Huang, CH Tseng, FS Chang…

文献索引：Chen, Yeh-Long; Huang, Chao-Jhieh; Huang, Zun-Yuan; Tseng, Chih-Hua; Chang, Feng-Shuo; Yang, Sheng-Huei; Lin, Shinne-Ren; Tzeng, Cherng-Chyi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3098 - 3105

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被引用次数: 48

摘要

The present report describes the synthesis and antiproliferative evaluation of certain 4- anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives. The antiproliferative activity of 4′-COMe-substituted derivatives decreased in an order of 6-OMe (1, 3.89 μM)> 8-OMe (8, 10.47 μM)> 8-OH (9, 14.45 μM), indicating that the position of substitution at the quinoline ring is crucial. For 3′-COMe derivatives, the ...