Abstract: Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxyarylbiguanides 8a-d have been prepared by condensing corresponding N-alkoxyamine salt 6a-c with substituted aryldicyandiamide 7, which in turn is prepared by Gabriel hydrolysis of ...
