4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer

PA Brough, W Aherne, X Barril…

文献索引：Journal of Medicinal Chemistry, , vol. 51, # 2 p. 196 - 218

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被引用次数: 304

摘要

... Journal of Medicinal Chemistry. ... However, these issues and the inherent chemical complexity of these ansamycin inhibitors have led to significant efforts to identify novel small-molecule inhibitors of Hsp90.(22, 32-37). figure ...