Novel hydroxyphosphonate inhibitors of CD-45 tyrosine phosphatase

RF Frechette, C Ackerman, S Beers, R Look…

文献索引：Frechette, Roger F.; Ackerman, Caridad; Beers, Scott; Look, Rich; Moore, John Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2169 - 2172

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被引用次数: 43

摘要

CD-45 tyrosine phosphatase [EC 3.1. 3.48] is an important player in the regulation of cell activation and proliferation in hematopoetic cells. As part of a program in immune response modulation, we prepared the first series of small organic molecule inhibitors of CD-45. The preparation and in vitro screening of these hydroxyphosphonates is described herein.