Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth

E Sadikoglou, G Magoulas, C Theodoropoulou…

文献索引：Sadikoglou, Eldem; Magoulas, George; Theodoropoulou, Christina; Athanassopoulos, Constantinos M.; Giannopoulou, Efstathia; Theodorakopoulou, Olga; Drainas, Denis; Papaioannou, Dionysios; Papadimitriou, Evangelia European Journal of Medicinal Chemistry, 2009 , vol. 44, # 8 p. 3175 - 3187

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被引用次数: 10

摘要

In the present work, a series of conjugates of amino acids with all-trans-retinoic acid (ATRA) and shorter polyene chain analogues were rationally designed, synthesized by coupling the succinimidyl active esters of the acidic retinoids with appropriately protected amino acids or peptides followed by deprotection, and examined for their possible effect on viability of human prostate cancer LNCaP cells. In contrast to ATRA, all conjugates bearing amino ...