Journal of the American Chemical Society

An Examination of the Use of Carbobenzyloxy-γ-L-glutamyl Hydrazide in the Synthesis of γ-Peptides1

H Sachs, E Brand

文献索引：Sachs; Brand Journal of the American Chemical Society, 1954 , vol. 76, p. 1815

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被引用次数: 7

摘要

In the past, the a-ester y-chloride of carbobenzyloxyglutamic acid3-'[symbol: Z. GIU. OE~]~ or LC1 phthalylglutamic anhydrideg have been used in the synthesis of y-peptides. Both of these methods are open to objection since at some stage they involve the opening of an N- acylglutamic anhydride ring which may yield mixtures of a-and y-derivatives.'O In order to circumvent this difficulty, the y-hydrazide of carbobenzyloxy-L-glutamic acid,[ZGlu. OH (L)], ...