Bioorganic & medicinal chemistry

Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors

X Li, R Vince

文献索引：Li, Xingnan; Vince, Robert Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5742 - 5755

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被引用次数: 42

摘要

Because of its essential role in HIV replication and lack of human counterpart, HIV integrase is an attractive target for the development of novel anti-AIDS agents. Among the recently developed integrase inhibitors, only the α, γ-diketo acid (DKA) compounds were biologically