N??Substituted Glutamyl Sulfonamides as Inhibitors of Glutamate Carboxypeptidase II (GCP2)
BR Blank, P Alayoglu, W Engen, JK Choi…
文献索引：Blank, Brian R.; Alayoglu, Pinar; Engen, William; Choi, Joseph K.; Berkman, Clifford E.; Anderson, Marc O. Chemical Biology and Drug Design, 2011 , vol. 77, # 4 p. 241 - 247
Glutamate carboxypeptidase II (GCP2) is a membrane-bound cell-surface peptidase which is implicated in several neurological disorders and is also over-expressed in prostate tumor cells. There is a significant interest in the inhibition of GCP2 as a means of neuroprotection, while GCP2 inhibition as a method to treat prostate cancer remains a topic of further investigation. The key zinc-binding functional group of the well-characterized classes of ...
