Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design

IC Choong, W Lew, D Lee, P Pham…

文献索引：Journal of Medicinal Chemistry, , vol. 45, # 23 p. 5005 - 5022

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被引用次数: 123

摘要

... Journal of Medicinal Chemistry. ... diseases such as rheumatoid arthritis and diseases involving dysregulated apoptosis such as myocardial infarction, stroke, traumatic brain injury, sepsis, Alzheimer's disease, and Parkinson's disease represent a large unmet medical need and ...