Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo [1, 2-a] imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF 1 R) …

D Zuev, VM Vrudhula, JA Michne, B Dasgupta…

文献索引：Zuev, Dmitry; Vrudhula, Vivekananda M.; Michne, Jodi A.; Dasgupta, Bireshwar; Pin, Sokhom S.; Huang, Xiaohua Stella; Wu, Dedong; Gao, Qi; Zhang, Jie; Taber, Matthew T.; MacOr, John E.; Dubowchik, Gene M. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3669 - 3674

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被引用次数: 7

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel series of [6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethyl]-dialkylamines was discovered as potent CRF 1 R antagonists. The optimization of binding affinity in the series by the parallel reaction approach is discussed herein. ... A novel series of [6-chloro-2- ...