Bioactive bromopyrrole metabolites from the Caribbean sponge Agelas conifera

…, RG Hughes Jr, D Rittschof, KL Rinehart

文献索引：Keifer, Paul A.; Schwartz, Robert E.; Koker, Moustapha E. S.; Hughes, Robert G.; Rittschof, Dan; Rinehart, Kenneth L. Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 2965 - 2975

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被引用次数: 192

摘要

Biologically active extracts of the Caribbean sponge Agelas conifera have yielded, in exhaustive studies, the diacetate salts of seven new bromopyrroles (1, 3-8), as well as that of the known debromooroidin dimer sceptrin (2). These compounds were found to be antiviral and antibacterial and were active in barnacle settlement and biochemical prophage induction assays. The structures assigned were based on spectroscopic comparisons to ...