5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl) pyrido [2, 3-d] pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non- …

…, S DiDomenico, GA Gfesser, A Gomtsyan…

文献索引：Matulenko, Mark A.; Lee, Chih-Hung; Jiang, Meiqun; Frey, Robin R.; Cowart, Marlon D.; Bayburt, Erol K.; DiDomenico Jr., Stanley; Gfesser, Gregory A.; Gomtsyan, Arthur; Guo, Zhu Zheng; McKie, Jeffery A.; Stewart, Andrew O.; Yu, Haixia; Kohlhaas, Kathy L.; Alexander, Karen M.; McGaraughty, Steve; Wismer, Carol T.; Mikusa, Joseph; Marsh, Kennan C.; Snyder, Ronald D.; Diehl, Marilyn S.; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Bhagwat, Shripad S. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3705 - 3720

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被引用次数: 41

摘要

4-Amino-5, 7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. In this report, we disclose the pharmacologic effects of five-and six-membered heterocyclic ring replacements for the pyridine ring in 4. These replacements were found ...