The discovery of new spirocyclic muscarinic M 3 antagonists

…, N Kindon, G Pairaudeau, J Theaker, DJ Warner

文献索引：Stocks, Michael J.; Alcaraz, Lilian; Bailey, Andrew; Bowers, Keith; Donald, David; Edwards, Helen; Hunt, Fraser; Kindon, Nicholas; Pairaudeau, Garry; Theaker, Jill; Warner, Daniel J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7458 - 7461

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被引用次数: 11

摘要

... free, Log D 2.2, MWt 405) and work is continuing in our laboratories to further optimize the chemical series. Acknowledgements. The authors thank Dr. Simon Teague and Dr. Tim Luker for helpful discussions. References and notes. 1; RM Eglen; Prog. Med. Chem., 43 (2005), p. 105. ... 2; I. Peretto, P. Petrillo, BP Imbimbo; Med. Res. Rev., 29 (2009), p. 867. ... Dramane I. Laine; Expert Rev. Clin. Pharmacol., 3 (2010), p. 43. ... M. Cazzola, MG Matera; Br. J. Pharmacol., 155 ...