Further optimization of sulfonamide analogs as EP1 receptor antagonists: synthesis and evaluation of bioisosteres for the carboxylic acid group

…, Y Aratani, H Kijima, H Yamamoto, T Maruyama…

文献索引：Naganawa, Atsushi; Matsui, Toshiaki; Ima, Masaki; Saito, Tetsuji; Murota, Masayuki; Aratani, Yoshiyuki; Kijima, Hideomi; Yamamoto, Hiroshi; Maruyama, Takayuki; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7121 - 7137

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被引用次数: 17

摘要

4-{[2-[(2-Furylsulfonyl)(isobutyl) amino]-5-(trifluoromethyl) phenoxy] methyl} benzoic acid analogs 2a and b and a series of the acid analogs, in which the carboxylic acid residue of 2b was replaced with various kinds of carboxylic acid bioisosteres, were synthesized and evaluated as EP1 receptor antagonists. Compound 2b and its monocyclic acid analogs, in which the carboxylic acid residue of 2b was replaced with monocyclic acid bioisosteres, ...