Based on the dramatic accelerating effect of 2-aminophenol, three ligands derived from 2- aminophenol were developed. Copper-catalyzed coupling reaction of nitrogen-containing nucleophiles with aryl bromides was efficiently carried out under mild conditions using 1, 2, 3, 4-tetrahydro-8-hydroxyquinoline as a novel, simple, and versatile ligand.
[Li, Zhenghua; Kumar, Amit; Vachhani, Dipak D.; Sharma, Sunil K.; Parmar, Virinder S.; Van Der Eycken, Erik V. European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2084 - 2091]
