AMONG the manifold physiological effects shown by compounds of the adrenaline series (I) is that of dilatation of the bronchioles,l and certain members, for example isoprenaline (I; R = Pri), find use in the treatment of asthmatic attacks. Several bicyclic systems also OH ... \ NHR 1.11) HO 0 CH(OH~.CH~.NHR Ho ' (I) R R ... 2 (a) RV Heinzelmann, B. D. Aspergen, and JH Hunter, J . Org. Chem., 1949, 14, 907; (b) N. Levin, BE Graham, and H. G. Kolloff, ibid., ...
