Ethacrynic acid analogues lacking the α, β-unsaturated carbonyl unit—Potential anti-metastatic drugs

…, EK Vogel, JL Wharton, CM Tilley, CN Kaminski…

文献索引：Janser, Romy F.J.; Meka, Ranjith K.; Bryant, Zack E.; Adogla, Enoch A.; Vogel, Elizabeth K.; Wharton, Jaimie L.; Tilley, Cynthia M.; Kaminski, Catherine N.; Ferrey, Seth L.; Van slambrouck, Severine; Steelant, Wim F.A.; Janser, Ingo Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1848 - 1850

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被引用次数: 5

摘要

A series of ethacrynic acid analogues, lacking the α, β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy ...