Tetrahedron

Synthesis and combinatorial approach of the reactivity of 6-and 7-arylthieno [3, 2-d][1, 3] oxazine-2, 4-diones

FX Le Foulon, E Braud, F Fabis, JC Lancelot, S Rault

文献索引：Le Foulon, Francois-Xavier; Braud, Emmanuelle; Fabis, Frederic; Lancelot, Jean-Charles; Rault, Sylvain Tetrahedron, 2003 , vol. 59, # 50 p. 10051 - 10057

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被引用次数: 25

摘要

This paper describes a general procedure for the synthesis of new substituted thiaisatoic anhydrides or 6-or 7-aryl-1H-thiéno [3, 2-d][1, 3] oxazine-2, 4-diones 3a–j and 4a–f. They were synthesized in large scale under microwave heating conditions with high yields. The reactivity vs nucleophilic reagents of these compounds was studied and permitted to develop a simple combinatorial procedure to synthesize a library of new thiophene ...