Relaxant activity of 4-amido-3, 4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis

…, AE Fenwick, CSV Houge-Frydrych…

文献索引：Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034

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被引用次数: 48

摘要

Cromakalim (BRL 34915, 1) is a member of a new class of pharmacologically active compounds, the potassium channel activators or openers, which have been extensively evaluated for their antihypertensive effects in animals.'A number of structurally distinct compounds have since been claimed which also relax vascular smooth muscle by a similar mechanism to that of cromakalim, but not all owe their antihypertensive action to this ...