A series of 3′-and 5′-carboxylated chalcones, 6-or 8-carboxylated flavones and 6- carboxylated flavanones,-flavanols and-flavans were prepared. The compounds were tested for their inhibitory activities against leukotriene D4 (LTD4) induced contraction of guinea-pig ileum. A new and convenient synthetic route to 3-acetyl-2-hydroxybenzoic acid (1d), a key intermediate for the synthesis of 3′-carboxy-2′-hydroxychalcones and 8-carboxylated ...
