Reactions with 2-thiothymine; selective cyclization of S-substituted 2-thiothymine

MM Youssef, AMS Youssef

文献索引：Youssef, Mohamed M.; Youssef, Ayman M. S. Phosphorus, Sulfur and Silicon and the Related Elements, 2003 , vol. 178, # 1 p. 67 - 81

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被引用次数: 6

摘要

2-Thiothymine (I) undergoes S-alkylation when treated with some halo compounds such as methyl and ethyl iodides. The S-alkyl derivatives II are treated with hydrazine hydrate to produce the hydrazine derivative III, which condensed with p-chlorobenzaldehyde to give p- chlorobenzaldehydepyrimidinehydrazone derivative IV. Compound II a reacts with phosphorus oxychloride to give 4-chloro derivative V. The chlorine atom in V undergoes ...