Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account

F Wu, FH Büttner, R Chen, E Hickey, S Jakes…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 11 p. 3235 - 3239

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被引用次数: 10

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Boehringer Ingelheim ... based on their similarity to Rho-Kinase in terms of sequence homology, phylogenetic relationship, biological relationship and chemical susceptibility, respectively. ...