Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

…, T Durand, R Escale, H Vial, Y Vo-Hoang

文献索引：Ouattara, Mahama; Wein, Sharon; Denoyelle, Severine; Ortial, Stephanie; Durand, Thierry; Escale, Roger; Vial, Henri; Vo-Hoang, Yen Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 624 - 626

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被引用次数: 12

摘要

Within the frame of the design of prodrug candidates to deliver a C-alkylamidine antimalarial agent, we showed that specific O-substitutions were needed on the alkylamidoxime structure. Among the newly synthesized molecules, bis-oxadiazolone and bis-O- methylsulfonylamidoxime derivatives induced a complete clearance of parasitemia in mice after oral administration.