Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid

…, Z Tan, S Tang, I Hewlett, R Pang, M He, S He…

文献索引：Li, Jiebo; Tan, Zhiwu; Tang, Shixing; Hewlett, Indira; Pang, Ruifang; He, Meizi; He, Shanshan; Tian, Baohe; Chen, Kan; Yang, Ming Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3177 - 3188

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被引用次数: 39

摘要

HIV-1 assembly and disassembly (uncoating) processes are critical for the HIV-1 replication. HIV-1 capsid (CA) and human cyclophilin A (CypA) play essential roles in these processes. We designed and synthesized a series of thiourea compounds as HIV-1 assembly and disassembly dual inhibitors targeting both HIV-1 CA protein and human CypA. The SIV- induced syncytium antiviral evaluation indicated that all of the inhibitors displayed antiviral ...