Development of a Scaleable Synthesis of NDT 9533750, a Key Intermediate to a Series of Novel Subtype Preferring GABAA Partial Agonists

Y Xu, B Han, ZQ Wang, KR Shaw…

文献索引：Organic Process Research and Development, , vol. 11, # 4 p. 716 - 720

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被引用次数: 3

摘要

... Organic Process Research & Development. ... Process Res. ... by refluxing with 2,2- dimethoxyethylamine and acetic acid gave imidine 12, which, upon acidification with 5 M HCl and heating, was converted to imidazole 2 (Scheme 4). This three-step one-pot procedure afforded ...