Tetrahedron

Synthesis of pyrazolo 3, 4-dpyrimidine analogues of the potent agent N-4-2-2-amino-4 3H-oxo-7H-pyrrolo 2, 3-dpyrimidin-5-yl ethylbenzoyl-L-glutamic acid ( …

EC Taylor, HH Patel

文献索引：Taylor, Edward C.; Patel, Hemantkumar H. Tetrahedron, 1992 , vol. 48, # 37 p. 8089 - 8100

全文：HTML全文

被引用次数: 192

摘要

Several pyrazolo [3, 4-d] pyrimidine analogues of the potent antitumor agent N-{4-[2-(2- amino-4 (3H)-oxo-7H-pyrrolo [2, 3-d] pyrimidin-5-yl) ethyl] benzoyl}-L-glutamic acid (LY231514, 5) have been prepared. A principal synthetic step proved to be a palladium- catalyzed C C coupling of the 5-halo-substituted pyrazolo [3, 4-d] pyrimidines 12–15 with dimethyl 4-ethynylbenzoyl-L-glutamate (16). An additional pyrazolo [3, 4-d] pyrimidine ...