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A new route to secondary amines from bis-(alkoxymethyl)-alkylamines-the activation of an aminomethyl group and protection of the product by the same functional …

MJ Earle, RA Fairhurst, H Heaney, G Papageorgiou…

文献索引:Earle, Martyn J.; Fairhurst, Robin A.; Heaney, Harry; Papageorgiou, George; Wilkins, Robert F. Tetrahedron Letters, 1990 , vol. 31, # 29 p. 4229 - 4232

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被引用次数: 25

摘要

Abstract Treatment of N, N-bis (alkoxymethyl) alkylamines with a variety of acidic reagents affords good yields of N-alkoxymethyl-N-alkylmethyleneiminium salts which react with trimethylsilyl enol ethers, and nucleophilic aromatic substrates to form protected ...