Discovery and SAR of 5-(3-chlorophenylamino) benzo [c][2, 6] naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the …

F Pierre, PC Chua, SE O'Brien…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 2 p. 635 - 654

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被引用次数: 123

摘要

... Journal of Medicinal Chemistry. ... figure Figure 1. Representative structures of known ATP-competitive inhibitors of CK2. The pharmaceutical industry's effort to develop CK2 inhibitors has been met with limited success. Vangrevelinghe et al. ...