Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... (S)-Prolinol facilitated the coupling reaction of terminal alkynes with 3-iodoflavone under palladium–copper catalysis in aqueous DMF affording a mild and convenient method for the synthesis of 3-alkynyl substituted flavones of potential biological interest. ... Diversity based flavone scaffold. ...