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Monatshefte für Chemie/Chemical Monthly

A convenient synthesis of 1-benzyl-1, 2, 3, 4-tetrahydroisoquinolines by combined Strecker/Bruylants reaction

E Reimann, C Ettmayr

文献索引:Reimann, Eberhard; Ettmayr, Christian Monatshefte fur Chemie, 2004 , vol. 135, # 10 p. 1289 - 1295

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被引用次数: 17

摘要

Summary. Strecker reaction of iodophenethylamines with phenylacetaldehydes afforded the corresponding α-aminonitriles, which on treatment with i-propyl magnesium chloride underwent a Bruylants reaction to give the title compounds. Their structures were deduced by NMR and by an independent preparation starting from papaverine. The educts were easily available by standard procedures.