Tetrahedron letters

Immobilized benzylpenicillin acylase: application to the synthesis of optically active forms of carnitin and propranalol

C Fuganti, P Grasselli, PF Seneci, S Servi, P Casati

文献索引：Fuganti; Grasselli; Seneci; et al. Tetrahedron Letters, 1986 , vol. 27, # 18 p. 2061 - 2062

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被引用次数: 49

摘要

Abstract The hydrolysis at pH 7.5 in the presence of immobilized benzylpenicillin acylase of the N-phenacetyl derivatives of the primary amines (3)-(5) affords the hydroxy amines (6)- (8), key intermediates in the synthesis of optically active forms of carnitin and propranalol, of ca. 0.4, 0.3 and 0.8 ee, respectively.