Design, synthesis, and structure–activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors

LJ Lombardo, A Camuso, J Clark, K Fager…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 7 p. 1895 - 1899

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被引用次数: 28

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Amide analogues did not suffer from chemical instability in the assay media and possessed biochemical potencies similar to 7e, but were considerably less potent in the cellular reversion assay and were not pursued further (data not ...