Synthesis of new thiazolo [3, 2-b][1, 2, 4] triazole-6 (5H)-one derivatives as potent analgesic and anti-inflammatory agents

MJ Assarzadeh, A Almasirad, A Shafiee…

文献索引：Assarzadeh, Mohammad Javad; Almasirad, Ali; Shafiee, Abbas; Koopaei, Mansur Nassiri; Abdollahi, Mohammad Medicinal Chemistry Research, 2014 , vol. 23, # 2 p. 948 - 957

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被引用次数: 7

摘要

Abstract A series of thiazolo [3, 2-b][1, 2, 4] triazole-6 (5 H)-ones were synthesized and evaluated for their analgesic and anti-inflammatory activities. The structures of these compounds were supported by FT-IR, 1 HNMR, and Mass spectra. All of the final compounds showed potent analgesic activity and the best compound 9d was 2.4 times more potent than mefenamic acid as the reference drug. In addition, most of them showed ...