Heterogeneous CuII??Catalysed Solvent??Controlled Selective N??Arylation of Cyclic Amides and Amines with Bromo??iodoarenes

…, S Bhadra, N Mukherjee, B Sreedhar…

文献索引：Kundu, Debasish; Bhadra, Sukalyan; Mukherjee, Nirmalya; Sreedhar, Bojja; Ranu, Brindaban C. Chemistry - A European Journal, 2013 , vol. 19, # 46 p. 15759 - 15768

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被引用次数: 13

摘要

Abstract A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalysed by Cu II/Al 2 O 3 has been achieved. This protocol has been employed for the synthesis of a library of arenes bearing a cyclic amide and an amine moiety at two ends, including a few scaffolds of therapeutic importance. The mechanism has been established based on detailed electron paramagnetic resonance (EPR) spectroscopy, X-ray ...