Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates

…, JAS Cavaleiro, A Gaspar, J Garrido, F Borges

文献索引：Menezes, Jose C.J.M.D.S.; Kamat, Shrivallabh P.; Cavaleiro, Jose A.S.; Gaspar, Alexandra; Garrido, Jorge; Borges, Fernanda European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 773 - 777

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被引用次数: 54

摘要

Long chain alkyl hydroxycinnamates (8–21) were synthesized from the corresponding half esters of malonic acid (5–7) and benzaldehyde derivatives by Knoevenagel condensation. The total antioxidant capacity of these hydroxycinnamyl esters was evaluated using DPPH and ABTS assays. The observed antioxidant activity was highest for esters of caffeic acid followed by sinapic esters and ferulic esters. The parameters for drug-likeness of these ...