Discovery of new Gram-negative antivirulence drugs: structure and properties of novel E. coli WaaC inhibitors

…, V Gerusz, G Le Fralliec, C Oliveira, S Floquet…

文献索引：Moreau; Desroy; Genevard; Vongsouthi; Gerusz; Le Fralliec; Oliveira; Floquet; Denis; Escaich; Wolf; Busemann; Aschenbrenner Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4022 - 4026

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被引用次数: 54

摘要

Heptosyltransferases such as WaaC represent promising and attractive targets for the discovery of new Gram-negative antibacterial drugs based on antivirulence mechanisms. We report herein our approach to the identification of the first micromolar inhibitors of WaaC and the preliminary SAR generated from this family of 2-aryl-5-methyl-4-(5-aryl-furan-2-yl- methylene)-2, 4-dihydro-pyrazol-3-ones identified by virtual screening.