… -3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in vivo Antitumor Activity: Discovery of (2 E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1 …

…, KL Howell, R Kashi, P Kwon, P Lassota…

文献索引：Cuadro; Matia; Garcia; Vaquero; Alvarez-Builla Synthetic Communications, 1991 , vol. 21, # 4 p. 535 - 544

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被引用次数: 133

摘要

... Volume: Page: ... A synthetic chemistry effort was initiated based on this general HDAI structure in parallel with a high ... Alkylation of aminoester 20 with 1-(2-bromoethyl)benzimidazole and subsequent treatment with hydroxylamine afforded hydroxamate 21. ...