Design, synthesis, and structure–activity relationship studies of a potent PACE4 inhibitor

A Kwiatkowska, F Couture, C Levesque…

文献索引：Kwiatkowska, Anna; Couture, Frederic; Levesque, Christine; Ly, Kevin; Desjardins, Roxane; Beauchemin, Sophie; Prahl, Adam; Lammek, Bernard; Neugebauer, Witold; Dory, Yves L.; Day, Robert Journal of Medicinal Chemistry, 2014 , vol. 57, # 1 p. 98 - 109

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被引用次数: 12

摘要

PACE4 plays an important role in the progression of prostate cancer and is an attractive target for the development of novel inhibitor-based tumor therapies. We previously reported the design and synthesis of a novel, potent, and relatively selective PACE4 inhibitor known as a Multi-Leu (ML) peptide. In the present work, we examined the ML peptide through detailed structure–activity relationship studies. A variety of ML-peptide analogues ...