Design of a “turn-off/turn-on” biosensor: understanding carbohydrate-lectin interactions for use in noncovalent drug delivery

BK Gorityala, Z Lu, ML Leow, J Ma…

文献索引：Gorityala, Bala Kishan; Lu, Zhiqiang; Leow, Min Li; Ma, Jimei; Liu, Xue-Wei Journal of the American Chemical Society, 2012 , vol. 134, # 37 p. 15229 - 15232

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被引用次数: 45

摘要

Understanding the binding specificity for carbohydrate-lectin recognition events(1) encompasses the intricate details associated with a cascade of biological events(2) that occur during molecular recognition as well as lectin-prompted drug delivery.(3) Carbohydrate-lectin interactions display extremely low affinity (dissociation constants 10 –6 –10 –7 M). To achieve maximum affinity in biological systems, carbohydrates usually display multivalency, allowing appropriate ...