Journal of heterocyclic chemistry

Synthesis of 1??(1, 1??dimethylethyl)??1H??pyrazole??4??carboxylate ester derivatives

JR Beck, MP Lynch

文献索引：Beck, James R.; Lynch, Michael P. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 693 - 695

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被引用次数: 16

摘要

Abstract Attempts to prepare ethyl 5-cyano-1-(1, 1-dimethylethyl)-1H-pyrazole-4-carboxylate (7) by the reaction of the corresponding 5-chloro derivative 1b with cyanide ion were unsuccessful. The chloro ester was synthesized from the corresponding amino ester la utilizing nonaqueous diazotization with nitrosyl chloride. An alternate process was developed which allowed the preparation of 7 from the corresponding 5-methyl ester 3 in ...