Tetrahedron

Regioselective synthesis and S-derivatization reactions of 4-and 6-trifluoromethyl-3-cyano-2 (1H)-pyridinethiones

…, EY Kruglova, AM Shestopalov, VV Semenov, AA Gakh…

文献索引：Kislyi, Victor P.; Nikishin, Kirill G.; Kruglova, Elena Ya.; Shestopalov, Alexandr M.; Semenov, Victor V.; Gakh, Andrei A.; Buchanan III Tetrahedron, 1996 , vol. 52, # 33 p. 10841 - 10848

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被引用次数: 22

摘要

The regioselective synthesis of the title compounds was developed on the basis of condensation reactions of trifluoroacetylacetone and its methyl enacetal with cyanothioacetamide in the presence of bases. Thus, the condensation of trifluoroacetyl- acetone with cyanothioacetamide yields predominantly 4-trifluoromethyl-6-methyl-3-cyano-2 (1H)-pyridinethiones, whereas the methyl enacetal of trifluoroacetylacetone gives ...