Fluorinated retinoic acids and their analogs. 1. Synthesis and biological activity of (4-methoxy-2, 3, 6-trimethylphenyl) nonatetraenoic acid analogs

…, S Srisethnil, PW Trown, O Bohoslawec

文献索引：Pawson; Chan; DeNoble; Han; Piermattie; Specian; Srisethnil; Trown; Bohoslawec; Machlin; Gabriel Journal of Medicinal Chemistry, 1979 , vol. 22, # 9 p. 1059 - 1067

全文：HTML全文

被引用次数: 37

摘要

(4-Methoxy-2, 3, 6-trimethylphenyl) nonatetraenoic acids, esters, and amides (analogues of retinoic acid) bearing a fluorine atom (s) or a trifluoromethyl group on the polyene side chain were synthesized. The biological activities of these compounds and of lo-, 12-, and 14- ...