Structure–activity relationship studies of 5-benzylaminoimidazo [1, 2-c] pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors

…, S Nakayama, M Ozawa, K Miyazawa, K Misawa…

文献索引：Hirabayashi, Akihito; Mukaiyama, Harunobu; Kobayashi, Hiroaki; Shiohara, Hiroaki; Nakayama, Satoko; Ozawa, Motoyasu; Miyazawa, Keiji; Misawa, Keiko; Ohnota, Hideki; Isaji, Masayuki Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 284 - 294

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被引用次数: 15

摘要

Zeta-associated protein, 70kDa (ZAP-70), a spleen tyrosine kinase (Syk) family kinase, is normally expressed on T cells and natural killer cells and plays a crucial role in activation of the T cell immunoresponse. Thus, selective ZAP-70 inhibitors might be useful not only for treating autoimmune diseases, but also for suppressing organ transplant rejection. In our recent study on the synthesis of Syk family kinase inhibitors, we discovered that novel ...