Structure–activity studies of a series of dipyrazolo [3, 4-b: 3′, 4′-d] pyridin-3-ones binding to the immune regulatory protein B7. 1

NJ Green, J Xiang, J Chen, L Chen, AM Davies…

文献索引：Green, Neal J.; Xiang, Jason; Chen, Jing; Chen, Lihren; Davies, Audrey M.; Erbe, Dave; Tam, Steve; Tobin, James F. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2991 - 3013

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被引用次数: 27

摘要

The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. To this end, specific small molecule inhibitors of human B7. 1 were identified and characterized. Herein, we report the identification of ...