Use of (S)??5??(2??Methylpyrrolidin??2??yl)??1H??tetrazole as a Novel and Enantioselective Organocatalyst for the Aldol Reaction

…, PWR Harris, D Barker, MA Brimble

文献索引：Tong, Sok-Teng; Harris, Paul W. R.; Barker, David; Brimble, Margaret A. European Journal of Organic Chemistry, 2008 , # 1 p. 164 - 170

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被引用次数: 19

摘要

Abstract The novel organocatalyst (S)-5-(2-methylpyrrolidin-2-yl)-1H-tetrazole (4) catalyzes the aldol reaction between acetone and various aldehydes with superior enantioselectivity to the existing organocatalysts (S)-proline (1) and (S)-5-(pyrrolidin-2-yl)-1H-tetrazole (3).(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)